Antivascular endothelial growth factor agents for wet age-related macular degeneration: an IRIS registry analysis.

Mathew W MacCumber, Justin S Yu, Alexandros Sagkriotis, Guruprasad B, Bhavya Burugapalli, Xiaoyu Bi, Neetu Agashivala, Charles C Wykoff

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 2023 Jun

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To evaluate treatment patterns and outcomes of patients in the United States who received antivascular endothelial growth factor (anti-VEGF) agents for wet age-related macular degeneration (AMD). Retrospective study PARTICIPANTS: Patients with wet AMD. Using the Intelligent Research in Sight Registry, we studied patients with wet AMD who received ≥1 anti-VEGF injection, who were ≥50 years old, and with ≥1.5 years of follow-up. Patients were grouped based on follow-up duration (in years): ≥1.5 (cohort 1), ≥2.5 (cohort 2), and ≥3.5 (cohort 3). Patient characteristics were similar between treatment groups. 36.8%, 34.5%, and 39.2% of ranibizumab, aflibercept, and all anti-VEGF eyes, respectively, had an injection interval <8 weeks in length at the end of year 1. Results were similar at year 2 and 3. In cohorts 1-3, visual acuity (VA) changes from baseline ranged from 0.3 to 0.7 (year 1), -1.3 to -1.7 (year 2), and -2.8 to -3.1 (year 3) Early Treatment Diabetic Retinopathy Study letters. By the end of year 3, 41%, 39%, and 42% of ranibizumab, aflibercept, and all anti-VEGF eyes, respectively, had discontinued treatment (no injection for >6 months). Approximately one-third of eyes had injection intervals <8 weeks in length at the end of year 1. VA was slightly better at the end of year 1 and declined after the first year despite treatment. By the end of year 3, more than one-third of eyes had discontinued treatment. Given the high treatment burden, wet AMD patients may benefit from more durable approaches that require less frequent dosing. Copyright © 2021 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Citation

Mathew W MacCumber, Justin S Yu, Alexandros Sagkriotis, Guruprasad B, Bhavya Burugapalli, Xiaoyu Bi, Neetu Agashivala, Charles C Wykoff. Antivascular endothelial growth factor agents for wet age-related macular degeneration: an IRIS registry analysis. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. 2023 Jun;58(3):252-261