Collagenous Gastritis: Characteristics and Response to Topical Budesonide.

Collagenous gastritis (CG) is a rare disorder characterized by subepithelial collagen deposition in the stomach. Standard medications have been only moderately successful in treating CG. We report results of a large, retrospective, open-label noncontrolled study of topical budesonide for CG, with an aim of establishing an alternative therapy for the disease. We identified patients treated for CG at Mayo Clinic (2000-2017) with topically targeted budesonide (TTB) in 2 formulations: open-capsule budesonide or compounded immediate-release budesonide capsule. Demographic, clinical, biochemical, and histologic variables were assessed for all patients before and after treatment. We identified 64 patients with CG (50 adults, 14 children). Most were female (68%), mean age was 41 ± 22.8 years, and body mass index was 23.1 ± 5.9 kg/m2. In most pediatric patients, CG presented with abdominal pain and anemia; in adults, CG presented more often with weight loss (P < .001). Collagenous sprue or colitis were more common in patients >50 years of age (83%) vs those 19-50 years of age (27%) or <19 years of age (50%) (P < .001). Of the patients treated with TTB, 89% had a clinical response to TTB (42% complete, 46% partial), and 88% had a histologic response (53% complete, 33% partial). Adults and children with CG have a wide variety of symptoms, and notably, TTB therapy produced clinical and histologic improvement after other therapy had failed. Copyright © 2022 AGA Institute. Published by Elsevier Inc. All rights reserved.

Citation

Rok Seon Choung, Ayush Sharma, Victor G Chedid, Imad Absah, Zongming Eric Chen, Joseph A Murray. Collagenous Gastritis: Characteristics and Response to Topical Budesonide. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Sep;20(9):1977-1985.e1

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PMID: 34864160

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