The role of pro- and antiangiogenic factors in angiogenesis process by Raman spectroscopy.

M Kopec, H Abramczyk

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2022 Mar 05

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Raman spectroscopy and Raman imaging are powerful techniques to monitor biochemical composition around blood vessel. The aim of this study was to understand the role of pro- and antiangiogenic factors in angiogenesis process. Raman imaging and Raman single spectrum measurements allow the diagnosis of cancer biochemical changes in blood vessel based on several biomarkers simultaneously. We have demonstrated that Raman imaging combined with statistical methods are useful to monitoring pro- and antiangiogenic factors responsible for angiogenesis process. In this work Raman markers of proangiogenic and antiangiogenic factors were identified based on their vibrational signatures. Obtained results can help understand how growing tumor create its vascular system. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Citation

M Kopec, H Abramczyk. The role of pro- and antiangiogenic factors in angiogenesis process by Raman spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Mar 05;268:120667