Thymic stroma and TFII-I: towards new targeted therapies.

Pierluigi Giuseppe Manti, Sebastiano Trattaro, Davide Castaldi, Martina Pezzali, Lorenzo Spaggiari, Giuseppe Testa

Trends in molecular medicine 2022 Jan

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Thymic epithelial tumors (TETs) have been characterized at the molecular level through bioptic sections and cell lines. Despite these advances, there is a need for a more thorough characterization of the thymic stroma in thymoma, particularly because of the diversity of cell types that populate the tumor and the absence of a healthy thymic counterpart. Recent work on healthy pediatric thymi - both in vitro and at the single-cell level - now sets the stage for new studies on their neoplastic counterparts. Furthermore, general transcription factor IIi (GTF2I), a thymoma-specific oncogene, as well as some of its SNPs, are increasingly associated with autoimmune disease, a significant feature of thymomas. We summarize recent discoveries in the field and discuss the development of new targeted therapies. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Pierluigi Giuseppe Manti, Sebastiano Trattaro, Davide Castaldi, Martina Pezzali, Lorenzo Spaggiari, Giuseppe Testa. Thymic stroma and TFII-I: towards new targeted therapies. Trends in molecular medicine. 2022 Jan;28(1):67-78