Genetic Suppression Meets Structure Prediction: Probing a Spore Germination Receptor Complex.

Anne Moir, David L Popham

Journal of bacteriology 2022 Feb 15

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Despite the thousands of spore germinant receptor operons identified in genomes of bacilli and clostridia, understanding how the three essential receptor components act as a signal transduction machine in germination remains limited. The paper by Amon et al. in this issue uses the classical genetic approach of suppression to define a region of likely interaction between the GerAA and GerAB proteins: it provides a first glimpse into potential events within the receptor complex (J. D. Amon, L. Artzi, and D. Z. Rudner, J Bacteriol 204:e00470-21, 2022, https://doi.org/10.1128/JB.00470-21).

Citation

Anne Moir, David L Popham. Genetic Suppression Meets Structure Prediction: Probing a Spore Germination Receptor Complex. Journal of bacteriology. 2022 Feb 15;204(2):e0057921