Pregnane glycosides from Adonis amurensis and their bioactivity.

Yue Yan, Di Zhou, Xuezheng Li, Yuan Feng, Xiaoyan Wen, Yajun Wang, Renbo An, Gang Chen, Ning Li

Phytochemistry 2022 Feb

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Seven undescribed pregnane glycosides named amurensides A-G and two known aglycones were isolated from the whole herb of Adonis amurensis Regel & Radde. Their structures were established based on 1D and 2D NMR spectroscopic analyses, high-resolution mass spectrometry, and acid hydrolysis. The cytotoxicity of all compounds against three tumor cell lines (HepG2, Caco-2, and A549) were evaluated. Among them, amurensides A-C and E showed moderate inhibitory effects on the growth of HepG2 cells, with IC50 values ranging from 15.6 to 48.7 μM (sorafenib, 7.5 ± 1.9 μM). Amurensides A、D and F displayed inhibitory effects on the growth of A549 cells with IC50 values of 18.8 ± 1.2, 12.4 ± 0.6, and 30.4 ± 0.1 μM (cis-platinum, 6.1 ± 0.1 μM), respectively. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Yue Yan, Di Zhou, Xuezheng Li, Yuan Feng, Xiaoyan Wen, Yajun Wang, Renbo An, Gang Chen, Ning Li. Pregnane glycosides from Adonis amurensis and their bioactivity. Phytochemistry. 2022 Feb;194:113046