Application of lung volume reduction surgery for a child with filamin A (FLNA) mutations.

Lindsay C Burrage, Jeffrey S Heinle, Robert H Cerfolio, Robert P Guillerman, Kalyani R Patel, Nahir C Santiago, Wynton C Hoover, George B Mallory

Pediatric pulmonology 2022 Jan

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Diffuse lung disease in early childhood due to mutations in the filamin A gene has been recently reported. Clinical outcomes vary among individuals indicating variability in phenotype but a substantial proportion of reported cases in early life have ended up in death or lung transplantation. We recently encountered a school-aged child in whom the diagnosis of a filamin A mutation was delayed and the natural history of emphysematous lung disease was altered by serial lung volume reduction surgeries. She eventually underwent a bilateral lung transplant and we report the natural history of her disease and treatments applied herein. © 2021 Wiley Periodicals LLC.

Citation

Lindsay C Burrage, Jeffrey S Heinle, Robert H Cerfolio, Robert P Guillerman, Kalyani R Patel, Nahir C Santiago, Wynton C Hoover, George B Mallory. Application of lung volume reduction surgery for a child with filamin A (FLNA) mutations. Pediatric pulmonology. 2022 Jan;57(1):224-230