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    Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses. © 2021 Wiley Periodicals LLC.


    Madeliene Stump, Harpinder Dhinsa, Jennifer Powers, Mary Stone. Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation. Pediatric dermatology. 2022 Jan;39(1):145-146

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    PMID: 34888940

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