Pathogenesis of Concanavalin A induced autoimmune hepatitis in mice.

Jianheng Hao, Weili Sun, Huichao Xu

International immunopharmacology 2022 Jan

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Autoimmune hepatitis (AIH) is an autoimmune disease characterized by liver parenchymal destruction and chronic fibrosis. Its exact etiology and pathogenesis are not yet fully understood.(Please connect with the following, do not leave a line) Concanavalin A (Con A)-induced mice hepatitis model is a liver injury mediated by T cell and macrophage activation, and its pathogenesis and pathological changes are similar to human AIH. The establishment of this model has greatly promoted the research progress of AIH pathogenesis. However, the exact mechanism of Con A induced liver injury in mice, and its possible defects or deficiencies, has not yet been described in a clear and detailed manner. Therefore, the model has some limitations when applied to the study of the pathogenesis and treatment mechanism of AIH. This article reveals the pathogenesis of Con A induced liver injury in mice from the aspects of immune disorder and coagulation mechanism, expounds the significance of non-coding RNA in this model, summarizes the signal transduction pathways involved in this model, and summarizes the advantages and disadvantages of the model, which provides a theoretical basis and research target for the application of Con A induced liver injury model in AIH in the future. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Jianheng Hao, Weili Sun, Huichao Xu. Pathogenesis of Concanavalin A induced autoimmune hepatitis in mice. International immunopharmacology. 2022 Jan;102:108411