Flavivirus-host interactions: an expanding network of proviral and antiviral factors.

William M Schneider, Hans-Heinrich Hoffmann

Current opinion in virology 2022 Feb

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Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions may ultimately lead to novel therapeutic targets. We highlight several studies that employed low-biased methods to discover new protein-protein, protein-RNA, and genetic interactions, and spotlight recent work characterizing the host protein, TMEM41B, which has been shown to be critical for infection by diverse flaviviruses and coronaviruses. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

William M Schneider, Hans-Heinrich Hoffmann. Flavivirus-host interactions: an expanding network of proviral and antiviral factors. Current opinion in virology. 2022 Feb;52:71-77