P2RY8-son" break of tolerance promotes SLE.

Maud Tusseau, Alexandre Belot

The Journal of experimental medicine 2022 Jan 03

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In this issue of JEM, He et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility and activation within the germinal center. © 2021 Tusseau and Belot.