Dynamic of humoral response to SARS-CoV-2 anti-Nucleocapsid and Spike proteins after CoronaVac vaccination.

Lucas Bochnia-Bueno, Sergio Monteiro De Almeida, Sonia Mara Raboni, Douglas Adamoski, Ludmilla Louise Moreira Amadeu, Suzana Carstensen, Meri Bordignon Nogueira

Diagnostic microbiology and infectious disease 2022 Mar

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This study aimed to calculate the seroconversion rate and IgG antibody dynamic range of the CoronaVac vaccine in healthcare workers (HCWs) after immunization. Serum samples from 133 HCWs from Southern Brazil were collected 1 day before (Day 0) and +10, +20, +40, + 60, +110 days after administering the vaccine's first dose. Immunoglobulin G (IgG) was quantified using immunoassays for anti-N-protein (nucleocapsid) antibodies (Abbott, Sligo, Ireland) and for anti-S1 (spike) protein antibodies (Euroimmun, Lübeck, Germany). Seroconversion by day 40 occurred in 129 (97%) HCWs for the S1 protein, and in 69 (51.87%) HCWs for the N protein. An absence of IgG antibodies (by both methodologies), occurred in 2 (1.5%) HCWs undergoing semiannual rituximab administration, and also in another 2 (1.5%) HCWs with no apparent reason. This study showed that CoronaVac has a high seroconversion rate when evaluated in an HCW population. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Lucas Bochnia-Bueno, Sergio Monteiro De Almeida, Sonia Mara Raboni, Douglas Adamoski, Ludmilla Louise Moreira Amadeu, Suzana Carstensen, Meri Bordignon Nogueira. Dynamic of humoral response to SARS-CoV-2 anti-Nucleocapsid and Spike proteins after CoronaVac vaccination. Diagnostic microbiology and infectious disease. 2022 Mar;102(3):115597