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The induction of T cell responses by vaccination is important for protection against infection. We have previously shown that immunization with a killed Streptococcus pneumoniae whole-cell vaccine (SPWCV) by either intranasal immunization or subcutaneous immunization induced T cell responses to SPWCV. Protection against colonization by S. pneumoniae is dependent on CD4+ IL-17A production induced by immunization. Here, we present detailed protocols for preparation of SPWCV, immunization of mice, and assay for T cell responses in blood and splenocytes in immunized mice. © 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.


Emily M Roy, Fan Zhang, Richard Malley, Ying-Jie Lu. Induction of T Cell Responses by Vaccination of a Streptococcus pneumoniae Whole-Cell Vaccine. Methods in molecular biology (Clifton, N.J.). 2022;2410:345-355

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PMID: 34914056

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