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Two new fusicoccane-type diterpenoids, streptooctatins A (1) and B (2), together with a known compound cyclooctatin (3) were isolated from Streptomyces sp. KCB17JA11. The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compounds 1 and 2 induced EGFP-LC3 puncta indicating autophagic activities against HeLa cells without cytotoxicity. Copyright © 2021 Elsevier Ltd. All rights reserved.


Jun-Pil Jang, Mina Jang, Gwi Ja Hwang, Min Hee Kim, Jong Seog Ahn, Sung-Kyun Ko, Jae-Hyuk Jang. Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11. Bioorganic & medicinal chemistry letters. 2022 Feb 01;57:128504

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PMID: 34922027

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