Electrochemical Difunctionalization of Terminal Alkynes: Access to 1,4-Dicarbonyl Compounds.

1,4-Dicarbonyl compounds are versatile scaffolds for the heterocycle synthesis, including the Paal-Knorr reaction. Herein, a feasible electrosynthesis method to access 1,4-dicarbonyl compounds has been developed from simple alkynes and 1,3-dicarbonyl compounds. When the undivided cell is combined with the constant current mode, aryl alkynes containing numerous medicinal motifs with 1,3-dicarbonyl esters or ketones react smoothly. External oxidant and catalyst-free conditions conform to the requirements of green synthesis.

Citation

Jingcheng Hu, Li Zeng, Jiayu Hu, Rui Ma, Xue Liu, Ying Jiao, Haoyu He, Siyu Chen, Zhexi Xu, Hongfei Wang, Aiwen Lei. Electrochemical Difunctionalization of Terminal Alkynes: Access to 1,4-Dicarbonyl Compounds. Organic letters. 2022 Jan 14;24(1):289-292

PMID: 34923826

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