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Loss of skeletal muscle (SkM) quality is associated with different clinical conditions such as aging, diabetes, obesity, cancer, and heart failure. Nutritional research has focused on identifying naturally occurring molecules that mitigate the loss of SkM quality induced by pathology or syndrome. In this context, although few human studies have been conducted, epicatechin (Epi) is a prime candidate that may positively affect SkM quality by its potential ability to mitigate muscle mass loss. This seems to be a consequence of its antioxidant and anti-inflammatory properties and its stimulation of mitochondrial biogenesis to increase myogenic differentiation, as well as its modulation of key proteins involved in SkM structure, function, metabolism, and growth. In conclusion, the Epi could prevent, mitigate, delay, and even treat muscle-related disorders caused by aging and diseases. However, studies in humans are needed. Copyright© Bentham Science Publishers; For any queries, please email at


Hermann Zbinden-Foncea, Mauricio Castro-Sepulveda, Jocelyn Fuentes, Hernan Speisky. Effect of Epicatechin on Skeletal Muscle. Current medicinal chemistry. 2022;29(6):1110-1123

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PMID: 34923936

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