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    The growth traits are economically important traits in sheep. Improving growth rates will increase the profitability of producers. The aim of this study was to identify alleles of CD8B (encoding T-cell surface glycoprotein CD8 beta chain) that are aberrantly expressed in different tissues and to assess the effects and associations of its different genotypes on weight and size traits in sheep. Using quantitative real-time reverse transcription PCR arrays, expression profiling of CD8B was performed in various organs and tissues. CD8B was ubiquitously expressed, with very high expression in the lung, spleen, lymph, duodenum, and liver. One intronic mutation (chr3:62,718,030 (Oar_rambouillet_v1.0, same below) G > A) was identified using pooled DNA sequencing. Subsequently, the variants (AA, AG, and GG) were genotyped using the KASPar® PCR single nucleotide polymorphism (SNP) genotyping system. The results of association analysis with body weight and body size traits in 1304 sheep showed that increases in multiple phenotypic traits correlated with the AA genotype (body weight, p < 0.05; body length, p < 0.05). Thus, SNP chr3:62,718,030 G > A is a promising molecular marker for marker-assisted selection in sheep breeding.


    Changchun Lin, Fadi Li, Xiaoxue Zhang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Qizhi Song, Jianghui Wang, Bubo Zhou, Jiangbo Cheng, Dan Xu, Wenxin Li, Liming Zhao, Weimin Wang. Expression and polymorphisms of CD8B gene and its associations with body weight and size traits in sheep. Animal biotechnology. 2023 Nov;34(4):1214-1222

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    PMID: 34928779

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