Malnutrition in children associated with low insulin-like growth factor binding protein-3 (IGFBP-3) levels.

This study aimed to compare serum levels of Insulin-like Growth Factor Binding Protein-3 in children with malnutrition and good nutritional status. This cross-sectional study included 41 participants consisting of 31 malnourished, 10 well-nourished children aged between 36 and 60 months. Demographic data of participants were obtained utilizing a questionnaire. Nutritional status was determined by calculating the Z-score of body weight for age, height for age, and body weight for height indices using the WHO classification. IGFBP-3 levels were determined by the Enzyme-Linked Immunosorbent Assay (ELISA) method. Median serum IGFBP-3 levels in malnourished children were found to be lower i.e. 0.35mcg/mL (minimum-maximum: 0.04-1.52mcg/mL) compared to well-nourished children 1.52ng/mL (minimum-maximum 0.47-3.17mcg/mL). Serum IGFBP-3 levels can be used as indicators to assess nutritional status. Copyright © 2021 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

Citation

Dwi Ayu Rahmawati, Aminuddin Aminuddin, Firdaus Hamid, Prihantono Prihantono, Burhanuddin Bahar, Veni Hadju. Malnutrition in children associated with low insulin-like growth factor binding protein-3 (IGFBP-3) levels. Gaceta sanitaria. 2021;35 Suppl 2:S275-S277

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PMID: 34929830

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