Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavioral, physiological, biochemical, and histological toxic effects were evaluated. Chalcone 43 produced mucus in feces, visceral damage (liver) and alterations in organ coefficient (kidney, p = 0.037 and brain, p = 0.008) when compared to the control group. In addition, histological analysis showed that this chalcone produced edema, inflammation and necrosis in the evaluated organs, although there was no significant difference with the control. None of the biochemical parameters differed significantly between the treatment groups at 40 mg/kg dose and the control. The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.


Karina Cancino, Inés Castro, Carlos Yauri, Valérie Jullian, Jorge Arévalo, Michel Sauvain, Vanessa Adaui, Denis Castillo. Toxicity assessment of synthetic chalcones with antileishmanial potential in BALB/c mice. Revista peruana de medicina experimental y salud publica. 2021 Jul-Sep;38(3):424-433

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 34932744

View Full Text