The electrophysiologic properties of gonadotropin-releasing hormone neurons.

Stephanie Constantin, Suzanne M Moenter, Richard Piet

Journal of neuroendocrinology 2022 May

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For about two decades, recordings of identified gonadotropin-releasing hormone (GnRH) neurons have provided a wealth of information on their properties. We describe areas of consensus and debate the intrinsic electrophysiologic properties of these cells, their response to fast synaptic and neuromodulatory input, Ca2+ imaging correlates of action potential firing, and signaling pathways regulating these aspects. How steroid feedback and development change these properties, functions of GnRH neuron subcompartments and local networks, as revealed by chemo- and optogenetic approaches, are also considered. © 2021 British Society for Neuroendocrinology.

Citation

Stephanie Constantin, Suzanne M Moenter, Richard Piet. The electrophysiologic properties of gonadotropin-releasing hormone neurons. Journal of neuroendocrinology. 2022 May;34(5):e13073