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Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial: the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells. © 2021 The Author(s).


Camila R R Barbosa, Justin Barton, Adrian J Shepherd, Michele Mishto. Mechanistic diversity in MHC class I antigen recognition. The Biochemical journal. 2021 Dec 22;478(24):4187-4202

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PMID: 34940832

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