Safety of topical administration of nasal decongestants and vasoconstrictors in paediatric nasal surgery - A systematic review.

A J Macmillan, K M Phoon, O Edafe

International journal of pediatric otorhinolaryngology 2022 Feb

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Topical intranasal decongestants are essential in nasal surgery to improve operative field. There are concerns regarding safety in paediatric population. Data on safety and safe dosage are limited. This systematic review evaluated the literature on safety and dosage of intranasal decongestant in paediatric population. We performed a systematic search of PubMed, EMBASE, Cochrane library for relevant articles. Quality assessment was done on included articles. A total of 10 articles were included: five case reports; three observational studies; and two randomised control trials. Decongestants evaluated were phenylephrine, oxymetazoline, epinephrine, xylometazoline, and cocaine. In total, 209 patients were included. Side effects reported included bradycardia, tachycardia and hypertension. These were mostly self-limiting and of no clinical compromise to the patients. A total of 4/209 (1.9%) of patients required treatment for these reported effects. No mortality was reported in the included studies. In the paediatric population, the literature suggests that when delivered in a pre-specified, controlled dosage, the haemodynamic effects of phenylephrine, oxymetazoline, xylometazoline are minimal and of no clinical significance. There is scope for further studies to establish safe dosage in the paediatric population given the paucity of current literature. Crown Copyright © 2021. Published by Elsevier B.V. All rights reserved.

Citation

A J Macmillan, K M Phoon, O Edafe. Safety of topical administration of nasal decongestants and vasoconstrictors in paediatric nasal surgery - A systematic review. International journal of pediatric otorhinolaryngology. 2022 Feb;153:111010