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In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physiological and pathological conditions, the modulation of inflammation through the cholinergic anti-inflammatory reflex has been proposed. In this review, we summarized the evidence supporting chemical stimulation with cholinergic agonists and vagus nerve stimulation as therapeutic strategies in the treatment of various central nervous system pathologies, and their effect on inflammation.


Ivan Emmanuel Ramos-Martínez, María Carmen Rodríguez, Marco Cerbón, Juan Carlos Ramos-Martínez, Edgar Gustavo Ramos-Martínez. Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases. International journal of molecular sciences. 2021 Dec 14;22(24)

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PMID: 34948222

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