Participation of interferons in psoriatic inflammation.

Hanjiang Gu, Yufei Zhang, Weihui Zeng, Yumin Xia

Cytokine & growth factor reviews 2022 Apr

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Interferons are multifunctional cytokines not expressed in the skin under normal physiological conditions. However, they are overexpressed in serum and skin lesions of patients with psoriasis and play an important role in the pathogenesis of the disease. Interferons act directly on skin resident cells and recruit and modulate inflammatory cells, thereby exacerbating psoriatic inflammation. They upregulate the expression of relevant cytokines and chemokines, facilitate excessive proliferation of keratinocytes, and enhance the formation of poorly differentiated dermal microvessels. In this review, we summarized the pathogenic effect of interferons on psoriasis and also discussed the therapeutic strategies targeting interferons. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Hanjiang Gu, Yufei Zhang, Weihui Zeng, Yumin Xia. Participation of interferons in psoriatic inflammation. Cytokine & growth factor reviews. 2022 Apr;64:12-20