B- and Plasma Cell Subsets in Autoimmune Diseases: Translational Perspectives.

B lymphocytes play a central role in immunity owing to their unique antibody-producing capacity that provides protection against certain infections and during vaccination. In autoimmune diseases, B cells can gain pathogenic relevance through autoantibody production, antigen presentation, and proinflammatory cytokine secretion. Recent data indicate that B and plasma cells can function as regulators through the production of immunoregulatory cytokines and/or employing checkpoint molecules. In this study, we review the key findings that define subsets of B and plasma cells with pathogenic and protective functions in autoimmunity. In addition to harsh B-cell depletion, we discuss the strategies that have the potential to reinstall the balance of pathogenic and protective B cells with the potential of more specific and personalized therapies. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Van Duc Dang, Ana-Luisa Stefanski, Andreia C Lino, Thomas Dörner. B- and Plasma Cell Subsets in Autoimmune Diseases: Translational Perspectives. The Journal of investigative dermatology. 2022 Mar;142(3 Pt B):811-822

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PMID: 34955289

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