Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Exercise intolerance is common in people with CF (pwCF), but not universal among all individuals. While associated with disease prognosis, exercise intolerance is not simply a reflection of the degree of lung disease. In people with severe CF, respiratory limitations may contribute more significantly to impaired exercise capacity than in those with mild-moderate CF. At all levels of disease severity, there are peripheral factors e.g., abnormal macro- and micro-vascular function that impair blood flow and reduce oxygen extraction, and mitochondrial defects that diminish metabolic efficiency. We discuss advances in understanding the central and peripheral mechanisms underlying exercise intolerance in pwCF. Exploring both the central and peripheral factors that contribute to exercise intolerance in CF can help inform the development of new therapeutic targets, as well as help define prognostic criteria. Copyright © 2021. Published by Elsevier B.V.


Jessica E Caterini, Felix Ratjen, Alan R Barker, Craig A Williams, Kate Rendall, Jane E Schneiderman, Greg D Wells. Exercise intolerance in cystic fibrosis-the role of CFTR modulator therapies. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2022 Mar;21(2):282-292

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 34955387

View Full Text