Ready Access to Densely Substituted Furans Using Tsuji-Wacker-Type Cyclization.

A competent method for the construction of highly substituted furans catalyzed by Pd(II) and Cu(II) chloride has been developed. The method provides easy access to di-, tri-, and tetrasubstituted furans from corresponding diols with relatively mild conditions in a unified strategy. The developed method has been successfully tested with more than 25 substrates, which resulted in furans of multiple substitution patterns with up to 84% isolated yields.

Citation

Dattatraya P Masal, Rahul Choudhury, Aman Singh, D Srinivasa Reddy. Ready Access to Densely Substituted Furans Using Tsuji-Wacker-Type Cyclization. The Journal of organic chemistry. 2022 Jan 07;87(1):556-568

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PMID: 34962781

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