Determining the adjusted initial treatment dose of warfarin anticoagulant medicine using kernel-based support vector regression.

A novel research field in bioinformatics is pharmacogenomics and the corresponding applications of artificial intelligence tools. Pharmacogenomics is the study of the relationship between genotype and responses to medical measures such as drug use. One of the most effective drugs is warfarin anticoagulant, but determining its initial treatment dose is challenging. Mistakes in the determination of the initial treatment dose can result directly in patient death. Some of the most successful techniques for estimating the initial treatment dose are kernel-based methods. However, all the available studies use pre-defined and constant kernels that might not necessarily address the problem's intended requirements. The present study seeks to define and present a new computational kernel extracted from a data set. This process aims to utilize all the data-related statistical features to generate a dose determination tool proportional to the data set with minimum error rate. The kernel-based version of the least square support vector regression estimator was defined. Through this method, a more appropriate approach was proposed for predicting the adjusted dose of warfarin. This paper benefits from the International Warfarin Pharmacogenomics Consortium (IWPC) Database. The results obtained in this study demonstrate that the support vector regression with the proposed new kernel can successfully estimate the ideal dosage of warfarin for approximately 68% of patients. Copyright © 2021. Published by Elsevier B.V.

Citation

Rouhollah Maghsoudi, Mitra Mirzarezaee, Mehdi Sadeghi, Babak Nadjar-Araabi. Determining the adjusted initial treatment dose of warfarin anticoagulant medicine using kernel-based support vector regression. Computer methods and programs in biomedicine. 2022 Feb;214:106589

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PMID: 34963093

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