Cefazolin-Induced Thrombocytopenia in a Patient with Polycythemia Vera Following Coronary Artery Bypass.

Racha Boulos, Katja Turner, Samiya Saklayen, William Perez, Manoj H Iyer

Seminars in cardiothoracic and vascular anesthesia 2022 Mar

filter terms:

Cefazolin is an antibiotic that is commonly administered perioperatively to reduce the risk of surgical site infections. Cephalosporins have a well-established safety profile, but have been associated with thrombocytopenia and neutropenia due to their myelosuppressive effects. While this effect may be benign in healthy patients undergoing minor surgery, it can be detrimental in patients with underlying hematologic disorders presenting for open-heart surgery. Herein, we discuss the first case in the literature of cefazolin-induced thrombocytopenia and severe coagulopathy in a patient with polycythemia vera (PCV) during a coronary artery bypass-grafting surgery.

Citation

Racha Boulos, Katja Turner, Samiya Saklayen, William Perez, Manoj H Iyer. Cefazolin-Induced Thrombocytopenia in a Patient with Polycythemia Vera Following Coronary Artery Bypass. Seminars in cardiothoracic and vascular anesthesia. 2022 Mar;26(1):83-85