Effect of taurine and camel milk on amyloid beta peptide concentration and oxidative stress changes in aluminium chloride-induced Alzheimer's disease rats.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by brain accumulation of amyloid-beta peptide, and oxidative stress (Huang et al., 2016). The study evaluated effects of taurine and camel milk (CM) on amyloid-beta peptide and malondialdehyde concentrations and haemolysis in AlCl3-model of Alzheimer's disease in rats. Thirty-five female Wistar rats were divided into seven groups (n=5); Normal saline (0.2 mL/mg body weight); AlCl3 (100 mg/kg); CM (33 mL/kg) (Khatoon et al., 2016); Taurine (50 mg/kg) (Cetiner et al., 2005); AlCl3 (100 mg/kg) + CM (33 mL/kg); AlCl3 (100 mg/kg) + Taurine (50 mg/kg) and AlCl3 (100 mg/kg) + CM (33 mL/kg) + Taurine (50 mg/kg). The administration via oral gavage, lasted for eight weeks. Rats were sacrificed, brain (hippocampal) and blood samples were collected for determination of amyloid-beta peptide 1-42 (Aβ) and malondialdehyde concentrations and haemolysis changes. The concentration of Aβ peptide decreased (P < 0.05) in AD + CM (7.46 ± 0.31 ng/L) and AD + CM + Taurine (9.20 ± 0.43 ng/L), when compared to controls. Malonaldehyde concentration in AD + Taurine decreased (P < 0.05) and superoxide dismutase activity increased (P < 0.05) in AD + CM and AD + CM + Taurine groups compared to controls. At 0.5 % NaCl, percentage haemolysis in AD rats (45.50 ± 1.19 %) was lower (P < 0.05) than in AD + Tau (49.75 ± 3.25 %), AD + CM (51.50 ± 3.00 %) and AD + CM + Tau (52.00 ± 1.70 %) rats. The haemolysis at 0.4 % NaCl was lowest (P < 0.05) in AD (66.00 ± 2.12 %) rats, compared to AD + Tau (71.00 ± 4.40 %), AD + CM (74.25 ± 3.70 %) and AD + CM + Tau (73.50 ± 3.00 %) rats. Percentage haemolysis at 0.5% NaCl concentration increased (P < 0.05) in AD + CM (53.60 ± 2.96 %) and AD + CM + Taurine (51.20 ± 1.53 %) when compared to the controls. Taurine and camel milk reduced the accumulation of Aβ peptide and ameliorated the oxidative stress damage by decreasing malondialdehyde concentrations and percentage haemolysis. © 2021 the Alzheimer's Association.

Citation

Teslim S Abdulkadir, Ahmed Sherif Isa, Fatima A Dawud, Joseph O Ayo, Mohammed D Mohammed. Effect of taurine and camel milk on amyloid beta peptide concentration and oxidative stress changes in aluminium chloride-induced Alzheimer's disease rats. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Dec;17 Suppl 12:e058642

PMID: 34971104

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