Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity.

Theodore J Kottom, Eva M Carmona, Andrew H Limper

Frontiers in immunology 2021

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Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism's cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions. Copyright © 2021 Kottom, Carmona and Limper.

Citation

Theodore J Kottom, Eva M Carmona, Andrew H Limper. Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity. Frontiers in immunology. 2021;12:798214