TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance.

Yoelsis Garcia-Mayea, Cristina Mir, Laia Carballo, Almudena Sánchez-García, Marina Bataller, Matilde E LLeonart

Biochimica et biophysica acta. Reviews on cancer 2022 Jan

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The tetraspanin (TSPAN) family constitutes a poorly explored family of membrane receptors involved in various physiological processes, with relevant roles in anchoring multiple proteins, acting as scaffolding proteins, and cell signaling. Recent studies have increasingly demonstrated the involvement of TSPANs in cancer. In particular, tetraspanin 1 (also known as TSPAN1, NET-1, TM4C, C4.8 or GEF) has been implicated in cell survival, proliferation and invasion. Recently, our laboratory revealed a key role of TSPAN1 in the acquired resistance of tumor cells to conventional chemotherapy (e.g., cisplatin). In this review, we summarize and discuss the latest research on the physiological mechanisms of TSPANs in cancer and, in particular, on TSPAN1 regulating resistance to chemotherapy. A model of TSPAN1 action is proposed, and the potential of targeting TSPAN1 in anticancer therapeutic strategies is discussed. Copyright © 2022 Elsevier B.V. All rights reserved.

Citation

Yoelsis Garcia-Mayea, Cristina Mir, Laia Carballo, Almudena Sánchez-García, Marina Bataller, Matilde E LLeonart. TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance. Biochimica et biophysica acta. Reviews on cancer. 2022 Jan;1877(1):188674