Expression of taste signaling elements in jejunal tissue in subjects with obesity.

Toshiaki Yasuo, G Craig Wood, Xin Chu, Peter Benotti, Christopher D Still, David D K Rolston, Robert F Margolskee, Yuzo Ninomiya, Peihua Jiang

Journal of oral biosciences 2022 Mar

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Taste-signaling proteins, which are expressed throughout the digestive tract, are involved in regulating metabolism and immunity. This study aimed to determine if these genes are expressed and altered in jejunal tissues from patients with extreme obesity who received bariatric surgery. Reverse transcription polymerase chain reaction revealed that phospholipase C beta 2 and transient receptor potential channel M5 expression was downregulated in the jejunum of patients with a body mass index above 50, whereas gustducin expression remained unchanged. Our data suggest that taste-signaling dysregulation might contribute to obesity. Copyright © 2022. Published by Elsevier B.V.

Citation

Toshiaki Yasuo, G Craig Wood, Xin Chu, Peter Benotti, Christopher D Still, David D K Rolston, Robert F Margolskee, Yuzo Ninomiya, Peihua Jiang. Expression of taste signaling elements in jejunal tissue in subjects with obesity. Journal of oral biosciences. 2022 Mar;64(1):155-158