Assessment of the measurement of canine and feline serum fibroblast growth factor-23 concentrations by automated chemiluminescence immunoassay.

Hirosumi Miyakawa, Huai-Hsun Hsu, Mizuki Ogawa, Yuichi Miyagawa, Naoyuki Takemura

The Journal of veterinary medical science 2022 Feb 23

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This study compared canine and feline fibroblast growth factor (FGF)-23 concentration measurements between automated chemiluminescence assay (CLEIA) and enzyme-linked immunosorbent assay (ELISA). Seventy serum samples each from dogs and cats were evaluated. FGF-23 measurements by CLEIA significantly correlated with those of ELISA in both dogs and cats. The Bland-Altman test showed that FGF-23 between CLEIA and ELISA had fixed and proportional biases, respectively, in both dogs and cats. Measurements by CLEIA were lower than those of ELISA, especially in higher serum FGF-23 concentrations. This study showed that FGF-23 concentrations in dogs and cats can be evaluated by automated CLEIA. However, FGF-23 cannot be directly compared between CLEIA and ELISA.

Citation

Hirosumi Miyakawa, Huai-Hsun Hsu, Mizuki Ogawa, Yuichi Miyagawa, Naoyuki Takemura. Assessment of the measurement of canine and feline serum fibroblast growth factor-23 concentrations by automated chemiluminescence immunoassay. The Journal of veterinary medical science. 2022 Feb 23;84(2):257-260