Reduced Numbers of Corticotropin-Releasing Hormone Neurons in Narcolepsy Type 1.

Ling Shan, Rawien Balesar, Dick F Swaab, Gert Jan Lammers, Rolf Fronczek

Annals of neurology 2022 Feb

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Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, whereas CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: that is, vasopressin, oxytocin, tyrosine hydroxylase, and thyrotropin releasing hormone-expressing neurons. Other hypothalamic cell groups, that is, the suprachiasmatic, ventrolateral preoptic, infundibular, and supraoptic nuclei and nucleus basalis of Meynert, were unaffected. The surprising selective decrease in CRH-neurons provide novel targets for diagnostics and therapeutic interventions. ANN NEUROL 2022;91:282-288. © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Citation

Ling Shan, Rawien Balesar, Dick F Swaab, Gert Jan Lammers, Rolf Fronczek. Reduced Numbers of Corticotropin-Releasing Hormone Neurons in Narcolepsy Type 1. Annals of neurology. 2022 Feb;91(2):282-288