Identification of β-aminopyrrolidine containing peptides as β-amyloid aggregation inhibitors for Alzheimer's disease.

Alzheimer's disease (AD) is caused by a series of events initiated by the production and aggregation of the amyloid β-protein (Aβ). In the early stages of the disease, Aβ is released in a soluble form then progressively forms oligomeric, multimeric, and fibrillar aggregates, triggering neurodegeneration. Thus, development of inhibitors that initiate reverse Aβ aggregation is thought to be a logical approach in treating AD. In this context, we developed β-aminopyrrolidine containing 12 mer peptide 3 which is very potent in inhibiting the Aβ aggregation and also reducing Aβ(42)-induced cytotoxicity. © 2022 European Peptide Society and John Wiley & Sons, Ltd.

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Habbanakuppe D Preetham, Umashankara Muddegowda, Kothanahally S Sharath Kumar, Shobith Rangappa, Kanchugarakoppal S Rangappa. Identification of β-aminopyrrolidine containing peptides as β-amyloid aggregation inhibitors for Alzheimer's disease. Journal of peptide science : an official publication of the European Peptide Society. 2022 Jun;28(6):e3386

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PMID: 34981876

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