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Stopping antidepressants can be challenging due to the high rate of discontinuation symptoms. Patients with antidepressant discontinuation syndrome (ADS) commonly experience insomnia, flu-like symptoms, mood disturbances, dizziness, and paresthesias, but a broad array of adverse effects is possible. Symptoms can last for days to months, and different symptoms have different durations. Patient education, identification of patients most at risk for developing symptoms, and a slow antidepressant taper or cross-taper are important steps in mitigating the risk of ADS and managing patient concerns about ADS. Tapers should be carried out over weeks to months. Discontinuation symptoms should be managed with restarting the prior dose of antidepressant and then tapering even more slowly, with additional symptomatic management as needed. Copyright © 2022 The Cleveland Clinic Foundation. All Rights Reserved.


Samantha J Zwiebel, Adele C Viguera. Discontinuing antidepressants: Pearls and pitfalls. Cleveland Clinic journal of medicine. 2022 Jan 04;89(1):18-26

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PMID: 34983798

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