Emerging Functions of IL-33 in Homeostasis and Immunity.

Gaelen K Dwyer, Louise M D'Cruz, Hēth R Turnquist

Annual review of immunology 2022 Apr 26

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Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these processes. In this review, we outline an evolving understanding of IL-33 immunobiology, paying particular attention to how IL-33 directs a network of ST2+ regulatory T cells, reparative and regulatory macrophages, and type 2 innate lymphoid cells that are fundamental to tissue development, homeostasis, and repair.

Citation

Gaelen K Dwyer, Louise M D'Cruz, Hēth R Turnquist. Emerging Functions of IL-33 in Homeostasis and Immunity. Annual review of immunology. 2022 Apr 26;40:15-43