Correlation Engine 2.0
Clear Search sequence regions

  • asthma (1)
  • cytokines (2)
  • homeostasis (5)
  • humans (1)
  • IL 1 (1)
  • IL 33 (6)
  • Interleukin 33 (2)
  • lymphocytes (2)
  • macrophages (1)
  • t cells (1)
  • Sizes of these terms reflect their relevance to your search.

    Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these processes. In this review, we outline an evolving understanding of IL-33 immunobiology, paying particular attention to how IL-33 directs a network of ST2+ regulatory T cells, reparative and regulatory macrophages, and type 2 innate lymphoid cells that are fundamental to tissue development, homeostasis, and repair.


    Gaelen K Dwyer, Louise M D'Cruz, Hēth R Turnquist. Emerging Functions of IL-33 in Homeostasis and Immunity. Annual review of immunology. 2022 Apr 26;40:15-43

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34985928

    View Full Text