RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.

Yingyun Yang, Xinyuan Cao, Lisong Huang, Aiming Yang

Molecular immunology 2022 Mar

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TANK-binding kinase 1 (TBK1) plays a pivotal role in antiviral innate immunity. TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-α/β) and of NF-κB signal transduction following viral infections. TBK1 must be tightly regulated to effectively control viral infections and maintain immune homeostasis. Here, we found that E3 ubiquitin ligase RNF19a mediated K48-linked ubiquitination and proteasomal degradation of TBK1. Specifically, the silence of RNF19a enhanced the production of type I interferons and suppressed RNA viral replication. Our results uncover that RNF19a acts as a negative mediator in the RIG-I signaling pathway to attenuate antiviral immune responses and suggest RNF19a as a potential therapy target in clinical infectious and inflammatory diseases. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Yingyun Yang, Xinyuan Cao, Lisong Huang, Aiming Yang. RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1. Molecular immunology. 2022 Mar;143:1-6