Blood caspase-8 concentrations and mortality among septic patients.

No data are available on blood caspase-8 concentrations (the initiator caspase in the extrinsic apoptosis pathway) in septic patients. The present study thus describes the blood caspase-8 concentrations in survivors and non-survivors, and examines the possible association between blood caspase-8 concentrations and mortality in septic patients. A prospective observational study was carried out. Three Spanish Intensive Care Units. Septic patients. Serum caspase-8 concentrations were determined at the diagnosis of sepsis. Mortality after 30 days. Patients not surviving at day 30 (n=81) compared to surviving patients (n=140) showed higher serum caspase-8 levels (p<0.001). Multiple logistic regression analysis found an association between serum caspase-8 levels>43.5ng/ml and mortality (OR=3.306; 95%CI=1.619-6.753; p=0.001). The area under the curve (AUC) for mortality predicted by serum caspase-8 levels was 67% (95% CI=60-73%; p<0.001). The novel findings of our study were that blood caspase-8 concentrations are higher in non-survivors than in survivors, and that there is an association between blood caspase-8 concentrations and mortality in septic patients. Copyright © 2020 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.

Citation

L Lorente, M M Martín, R Ortiz-López, A F González-Rivero, A Pérez-Cejas, M Martín, V Gonzalez, A Pérez, M Rodin, A Jiménez. Blood caspase-8 concentrations and mortality among septic patients. Medicina intensiva. 2022 Jan;46(1):8-13

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PMID: 34991877

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