Evaluation of cytotoxic activity of Fe doped cobalt oxide nanoparticles.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2022 Mar

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This contribution of work describes a new strategy for manufacturing cobalt oxide nanoparticles and the results assured that, its efficiency was increased by adding Fe ions. The anticancer drugs usually have a limited medical value owing to their nonspecific cytotoxicity. It has been proven that by using the nanosystems to deliver tablets to tumour cells reduces the toxic quality. Because of these qualities, nanoparticles can be used as a stronger rival for potent cancer treatment. This study investigated the cytotoxicity of iron doped cobalt oxide nanoparticles through trypan blue exclusion method. The newly generated Fe doped Co3O4 nanoparticles had proved its biocompatibility from the report of reduced toxicity below 200 μg/mL on malignant cell lines. The observed findings may encourage the development of anticancer drugs based on the inorganic particles, especially Fe doped Co3O4 nanoparticles, that could be serve as an excellent framework for the drug delivery and provide a new perspective for interpreting and targeting various therapeutic methodologies to tumours. Copyright © 2021 Elsevier GmbH. All rights reserved.

Citation

C S Jincy, P Meena. Evaluation of cytotoxic activity of Fe doped cobalt oxide nanoparticles. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2022 Mar;70:126916