Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients.

Jiayang Sun, Chen Zhan, Zheng Deng, Wei Luo, Qiaoli Chen, Mei Jiang, Nanshan Zhong, Kefang Lai

Thorax 2022 Jun

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Chronic refractory cough (CRC) is characterised by cough hypersensitivity. Interferon-γ (IFN-γ) has been reported to induce calcium influx, action potentials of vagal neurons in vitro and cough response in guinea pigs. While the effect of IFN-γ in CRC patients remains unknown. Here, via flow-cytometry and inhalation cough challenge, we found CRC patients had significantly increased levels of sputum IFN-γ+CD4+ T cells, IFN-γ+CD8+ T cells as well as supernatant of IFN-γ. The average number of coughs in CRC patients increased as the concentration of inhaled IFN-γ went up in IFN-γ cough challenge. Two or more coughs and five or more coughs elicited by inhaled IFN-γ in CRC patients occurred in 7 of 10 and 2 of 10, respectively. Preinhaled IFN-γ (100 µg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers. Targeting IFN-γ may be a potential effective anti-tussive strategy in CRC patients. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Jiayang Sun, Chen Zhan, Zheng Deng, Wei Luo, Qiaoli Chen, Mei Jiang, Nanshan Zhong, Kefang Lai. Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients. Thorax. 2022 Jun;77(6):621-624