Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials.

Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and Plasmodium ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization. © 2022 British Pharmacological Society.

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Nicholas J White, James A Watson, J Kevin Baird. Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials. British journal of clinical pharmacology. 2022 Jun;88(6):2657-2664

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PMID: 34997616

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