Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity.

Aristine Cheng, Steven M Holland

The Journal of allergy and clinical immunology 2022 Jan

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Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes. Copyright © 2021. Published by Elsevier Inc.

Citation

Aristine Cheng, Steven M Holland. Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity. The Journal of allergy and clinical immunology. 2022 Jan;149(1):24-28