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Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course. Copyright © 2020 Sociedad Española de Neurocirugía. Published by Elsevier España, S.L.U. All rights reserved.


Pedro Valente Aguiar, Osvaldo Sousa, Roberto Silva, Rui Vaz, Paulo Linhares. Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping. Neurocirugia (English Edition). 2022 Jan-Feb;33(1):31-34

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PMID: 34998489

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