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A 4-month-old boy with abdominal distension was diagnosed with adrenal neuroblastoma with numerous metastases to the liver and nodules in the skin and muscles. Marked hepatomegaly spontaneously regressed with decreasing tumor marker levels, and the final diagnosis was stage M based on radiologic findings confirming metastasis to the pancreas. The neuroblastoma did not have the MYCN amplification but had an 11q aberration. Chemotherapy was initiated at age 6 months with a successful response. Our case reflects the heterogenous clinical behavior of neuroblastoma and highlights the challenging issue of the difference between stage M and stage MS neuroblastoma in infants. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Yuri Yoshimoto Suzuki, Junko Yamanaka, Osamu Miyazaki, Kumiko Nozawa, Miki Ohira, Takehiko Kamijo, Hiroyuki Shichino. Infantile Stage M Neuroblastoma With 11q Deletion, Mimicking Stage MS. Journal of pediatric hematology/oncology. 2022 Apr 01;44(3):e779-e781

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PMID: 35001057

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