Electrochemical Sensing of Adenosin Triphosphate by Specific Binding to Dipicolylamine Group in Cyclodextrin Supramolecular Complex.

Maria Antonietta Casulli, Irene Taurino, Takeshi Hashimoto, Sandro Carrara, Takashi Hayashita

ACS applied bio materials 2021 Apr 19

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Electrochemical detection based on cyclodextrin supramolecular complexes is founded on the competitive binding between electroactive probes and target molecules. This limits their versatility to be used for sensing a broad range of metabolites. In this work, we demonstrate the significant role of zinc ions as well as of β-cyclodextrins modified with dipicolylamine and of a phenylboronic acid-modified ferrocene probe to address a selective electrochemical detection of adenosin triphosphate (ATP). Our findings will definitively have an impact in oncological point-of-care systems, since a high level of extracellular ATP reveals the inflammatory response due to chemotherapeutic treatments.

Citation

Maria Antonietta Casulli, Irene Taurino, Takeshi Hashimoto, Sandro Carrara, Takashi Hayashita. Electrochemical Sensing of Adenosin Triphosphate by Specific Binding to Dipicolylamine Group in Cyclodextrin Supramolecular Complex. ACS applied bio materials. 2021 Apr 19;4(4):3041-3045