Zisong Bai, Di Zhou, Qingqi Meng, Mingxia Fang, Gang Chen, Yue Hou, Ning Li
Natural product research 2023 MayStructurally diverse biflavonoids have attracted significant research interest for drug discovery over past decades. Biflavonoid oriented phytochemistry research on the stems of Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa was carried out, which resulted in the identification of ten major effective components (1-10), including the undescribed biflavonoids, daphnodorin Q (1), daphnodorin R (2) and flavane, daphnekiuslin A (10). The known structures were identified from this herb for the first time. Their structures were determined by combination of multiple spectroscopic data as well as calculated electronic circular dichroism (ECD). All the identified compounds were evaluated for the anti-neuroinflammatory effects. Compound 9 could inhibit the overactivation of BV-2 cells induced by lipopolysaccharide with IC50 value at 26.32 μM.
Zisong Bai, Di Zhou, Qingqi Meng, Mingxia Fang, Gang Chen, Yue Hou, Ning Li. Characteristic biflavonoids from Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa. Natural product research. 2023 May;37(9):1557-1564
PMID: 35014919
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