Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development.

Neoklis Makrides, Qian Wang, Chenqi Tao, Samuel Schwartz, Xin Zhang

Open biology 2022 Jan

filter terms:

A central question in development biology is how a limited set of signalling pathways can instruct unlimited diversity of multicellular organisms. In this review, we use three ocular tissues as models of increasing complexity to present the astounding versatility of fibroblast growth factor (FGF) signalling. In the lacrimal gland, we highlight the specificity of FGF signalling in a one-dimensional model of budding morphogenesis. In the lens, we showcase the dynamics of FGF signalling in altering functional outcomes in a two-dimensional space. In the retina, we present the prolific utilization of FGF signalling from three-dimensional development to homeostasis. These examples not only shed light on the cellular basis for the perfection and complexity of ocular development, but also serve as paradigms for the diversity of FGF signalling.

Citation

Neoklis Makrides, Qian Wang, Chenqi Tao, Samuel Schwartz, Xin Zhang. Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development. Open biology. 2022 Jan;12(1):210265