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Being an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered altered expressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs), forming a multi-tRNA synthetase complex (MSC) and divulging into their roles outside the range of protein synthesis. In this review, we have directed our focus into the rudimentary structure of this compact association and also how these aaRSs and AIMPs are involved in the maintenance and progression of lung cancer, the principal cause of most cancer-related deaths. There is substantial validation that suggests the crucial role of these prime housekeeping proteins in lung cancer regulation. Here, we have addressed the biological role that the three AIMPs and the aaRSs play in tumorigenesis, along with an outline of the different molecular mechanisms involved in the same. In conclusion, we have introduced the potentiality of these components as possible therapeutics for the evolution of new-age treatments of lung tumorigenesis. Copyright© Bentham Science Publishers; For any queries, please email at


Pratyasha Bhowal, Priyanka Biswas Karmakar, Debkanya Dey, Riya Manna, Debraj Roy, Rajat Banerjee. Aminoacyl-tRNA Synthetases, Indispensable Players in Lung Tumorigenesis. Protein and peptide letters. 2022;29(3):208-217

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PMID: 35016593

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